Which drugs are most effective in treating hair loss in men: JAMA Study

2022-05-03 0 By

Receding hairlines and bald spots on the top of the head are problems that most men face throughout their lives.Statistics show that around 90 percent of men will suffer some form of hair loss during their lifetime, and these problems can also lead to symptoms of anxiety and depression.Previously, there has been limited research on what non-surgical treatments are most effective for male baldness, also known as male alopecia.A meta-analysis of 23 studies, published February 3 in JAMA Dermatology, sheds light on how oral and topical drugs work best for hair loss.This meta-analysis examined the effects of different doses of three oral and topical drugs — minoxidil, dutaride, and finasteride — on thinning hair in men at 2 to 4 months.”Although the ideal study would be a randomized controlled clinical trial comparing the effects of these drugs on male alopecia areata, this meta-analysis is still important.””Commented Dr. Anthony Rossi, a dermatologist at Memorial Sloan-Kettering Cancer Center in New York City, who was not involved in the study.This analysis showed that oral administration of 5 mg of tartaride per day was most likely to reduce hair loss in men.Dutaride is a prescription drug approved by the US Food and Drug Administration (FDA), but the drug is mainly used to treat prostate hyperplasia in men, not hair loss.Studies have shown that dutaride, while effective at treating hair loss, can cause more serious side effects than other treatments, including loss of libido, erectile dysfunction and low blood pressure.Another oral medication, finasteride, at 5 mg per day, was the second most effective for hair loss.Finasteride is in the same chemical family as Dutaride and is also used to treat prostate hyperplasia, but the drug has been approved by the US FDA to treat hair loss.The finasteride group had the largest increase in total hair — both old hair and new “baby hair” — at week 48 of the drug, the study showed.”Finasteride can also affect male sexual performance, but the side effects are not as strong as dutaride, so it may be a better option for some men.””A lot of people take a gradual approach, starting with a low dose or external medication, and if it doesn’t improve then trying something with a bigger side effect,” Professor Rossi said.The third most effective treatment for male alopecia was oral administration of 5 mg minoxidil per day, which was much more effective than low-dose oral administration of 0.25 mg minoxidil.The drug produced the largest amount of “mature” hair at 48 weeks of administration, which is more likely to produce the “full hair” effect many seek than tiny “baby hair.”Fourth through sixth place were 1 mg finasteride daily dose and 5 percent minoxidil topical solution and 2 percent minoxidil topical solution on the scalp.As for the rankings, the researchers said that while the study ultimately ranked the treatments in descending order, each treatment had different benefits at different times during the 24 – and 48-week periods, and each treatment had associated side effects.”In general, topical drugs certainly have fewer systemic side effects than oral drugs, but they need to be used in accordance with the guidelines, which some people find troublesome.”A dermatologist told China Business News.Minoxidil is now the most common over-the-counter drug treatment for hair loss, including solution foaming agent and shampoo, through sooner or later, daub on the scalp hair loss treatment, side effects may include the scalp itching or burning, but work more slowly, it usually takes a few months to appear, and when to stop using, hair loss will recover soon.The researchers cautioned that none of the results of the study should apply to women with hair loss, especially women of childbearing age who should not receive any oral medications.The only drugs approved for women in the study were minoxidil 2% and 5% topical solutions.Declaration: The copyright of this article belongs to the original author, if there is a source error or infringement of your legitimate rights and interests, you can contact us through the mailbox, we will promptly deal with.Email address: jpbl@jp.jiupainews.com